State of the Science Symposium

The BMT CTN has sponsored four State of the Science Symposia, the most recent in March 2021. The purpose of the 2021 Symposium was to identify clinical trial concepts that: 1) Represent the most important issues facing the field; 2) Have the potential to change practice in a significant way; and 3) Require a multicenter network to be done effectively. Thirteen committees were convened to review the landscape:

  • Clinical Trial Design
  • Comorbidity and Regimen Related Toxicity
  • Disparities and Access to HCT
  • GVHD
  • Hemoglobinopathies
  • Infections / Immune Reconstitution
  • Late Effects / Quality of Life / Economics
  • Lymphoid Malignancies
  • Myeloid Malignancies
  • Non-Malignant Disorders
  • Optimal Donor & Graft Source
  • Pediatric Malignant Diseases
  • Plasma Cell Disorders

Eleven of the committees submitted 1-3 clinical trial proposals for review at the Symposium. The other two committees, Clinical Trial Design and Disparities and Access to HCT, served as advisory groups to the other committees. Prior to the Symposium, 22 external reviewers were invited to participate and review concepts in the areas of their expertise. These reviewers, the majority of whom are from outside the United States, reviewed the concepts prior to the Symposium and provided feedback to the Committee Chairs. Online feedback was also solicited from the HCT community at large. Based on external reviewer and online feedback, 15 study concepts were selected for presentation at the 1-day virtual Symposium. At the Symposium, Committee Chairs presented their concepts and then the session was opened to the audience for their input. Immediately following the Symposium, a survey was sent to participants to solicit their scores for the concepts. The day after the Committee Chairs and BMT CTN leadership team met to review the scores and prioritize the top studies. These 2021 priority concepts will serve as a road map for future studies recommended for implementation by the US transplant community using the resources of the BMT CTN, NCI Cooperative Groups, and other programs.

SOSS Documents