State of the Science Symposium

The BMT CTN has sponsored three State of the Science Symposia, the most recent in February 2014. The 2014 Symposium had two purposes: 1) to review recent scientific advances in the field of stem cell transplantation; and 2) to identify the most compelling opportunities for clinical research appropriate for our Network in the next several years. Thirteen committees were convened to review the landscape and present study proposals:

  • Clinical Trial Design
  • Comorbidity and Regimen Related Toxicity
  • Gene & Cell Therapy
  • GVHD
  • Infection / Immune Reconstitution
  • Late Effects / Quality of Life / Economics
  • Leukemia
  • Lymphoma
  • Multiple Myeloma
  • Non-Malignant Diseases
  • Optimal Donor & Graft Source
  • Pediatric Transplant—Indications / Approaches
  • Pediatric Transplant—Outcomes / Late Effects

Twelve of the committees submitted 1-3 clinical trial proposals for review at the Symposium. The thirteenth committee, Clinical Trial Design, served as an advisory group to the other committees. Prior to the Symposium, 20 external reviewers were invited to participate and review concepts in the areas of their expertise.  These reviewers, none of whom are involved directly with the BMT CTN (and the majority of whom are from outside the United States), reviewed the concepts prior to the Symposium and provided feedback to the Committee Chairs. At the Symposium, each Committee Chair presented a summary of their concepts, the reviewers presented their feedback and then the conversation was opened to the audience for their input. Each concept was scored during the Symposium by Committee Chairs, external reviewers and NIH Project Officers. Immediately following the Symposium, this group met to review the scores and prioritize the top studies.  The prioritized concepts were subsequently reviewed and agreed upon by the BMT CTN Executive and Steering Committees.  These 2014 priority concepts will serve as a road map for future studies recommended for implementation by the US transplant community using the resources of the BMT CTN, NCI Cooperative Groups, and other programs.

SOSS Documents