About STOPSC

STOPSC Eligibility Criteria

The specific eligibility criteria are:

Inclusion criteria:

ADULTS ( > 18 years of age)

Large Duct PSC:  

  1. Increased serum alkaline phosphatase as a marker for cholestasis.
  2. Endoscopic retrograde cholangiopancreatography (ERCP), intraoperative cholangiogram, percutaneous transhepatic cholangiogram (PTC) or magnetic resonance cholangiopancreatography (MRCP) evidence of intrahepatic and/or extrahepatic bile duct irregularities consistent with PSC.

Small Duct PSC:  

  1. Increased serum alkaline phosphatase as a marker for cholestasis.
  2. No endoscopic retrograde cholangiopancreatography (ERCP), intraoperative cholangiogram, percutaneous transhepatic cholangiogram (PTC) or magnetic resonance cholangiopancreatography (MRCP) evidence of intrahepatic and/or extrahepatic bile duct irregularities consistent with PSC.
  3. Either Inflammatory Bowel Disease (IBD) or Liver biopsy abnormalities consistent with chronic biliary injury.

PSC/AIH overlap:

  1. Meets criteria for large and small duct PSC.
  2. Liver histology with features of both PSC and AIH.

CHILDREN (<18 years of age)

PSC (2 of 3 needed):

  1. Serum alkaline phosphatase or GGT increased more than 50% above the upper limit of normal for age.
  2. ERCP, PTC or MRCP findings of intrahepatic under/or extrahepatic bile duct irregularities consistent with PSC.
  3. Liver biopsy abnormalities consistent with chronic biliary injury.

PSC/AIH overlap:

  1. Meets criteria for PSC.
  2. Liver histology with features of both PSC and AIH.

AIH:

  1. Meets definite or probable criteria for the International Autoimmune Hepatitis Working group (Journal of Hepatology 31:929, 1999).
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