Objectives of STOPSC

The specific research objectives of STOPSC are:

  1. To identify risk factors, including genetic and environmental factors, in the development of PSC and to understand how PSC starts and worsens.
  2. To identify the role genetic factors play in the development and treatment of the disease.
  3. To help develop diagnostic tests and approaches that can diagnose the disease in its early stages, as well as indicators for the severity, progression and response to treatment of the disease.
  4. To evaluate and compare the effectiveness and safety of various treatments of PSC.
  5. To collect information that will help characterize the disease and clarify the relationship between childhood and adult forms of PSC.
  6. To study the natural history and clinical course of the disease in children and adults.
  7. To better understand the relationship of PSC with associated diseases such as autoimmune hepatitis, and inflammatory bowel disease.
  8. To identify risk factors and biomarkers for the development of cholangiocarcinoma.
  9. To develop and test models which predict patient outcomes (cirrhosis, portal hypertension, cholangiocarcinoma, death, transplantation, etc.).
  10. To characterize and follow trends in therapies of PSC.