The specific research objectives of STOPSC are:
- To identify risk factors, including genetic and environmental factors, in the development of PSC and to understand how PSC starts and worsens.
- To identify the role genetic factors play in the development and treatment of the disease.
- To help develop diagnostic tests and approaches that can diagnose the disease in its early stages, as well as indicators for the severity, progression and response to treatment of the disease.
- To evaluate and compare the effectiveness and safety of various treatments of PSC.
- To collect information that will help characterize the disease and clarify the relationship between childhood and adult forms of PSC.
- To study the natural history and clinical course of the disease in children and adults.
- To better understand the relationship of PSC with associated diseases such as autoimmune hepatitis, and inflammatory bowel disease.
- To identify risk factors and biomarkers for the development of cholangiocarcinoma.
- To develop and test models which predict patient outcomes (cirrhosis, portal hypertension, cholangiocarcinoma, death, transplantation, etc.).
- To characterize and follow trends in therapies of PSC.